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Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2O2‐induced damage via NAMPT and the NF‐κB p65 signaling pathway.

An increasing number of studies have shown that nicotinamide mononucleotide (NMN) can inhibit not only ageing but also oxidative stress and inflammatory reactions by improving energy metabolism. However, the role…

Resveratrol Protects Cognition in Alzheimer’s Mice Fed High-Fat Diets

In recent years, caloric overconsumption derived mostly from saturated fat has contributed to the global obesity pandemic and the development of metabolic and brain disorders. Growing evidence in humans and…

Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons

Diabetes predisposes to cognitive decline leading to dementia and is associated with decreased brain NAD+ levels. This has triggered an intense interest in boosting nicotinamide adenine dinucleotide (NAD+) levels to prevent…

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and…

Mechanisms of transformation of nicotinamide mononucleotides to cerebral infarction hemorrhage based on MCAO model

Objective: The study aims at discussing the effect of nicotinamide mononucleotides on protecting hemorrhagic transformation of cerebral infarction in the middle cerebral artery occlusion (MCAO) model. Results: Compared with the other two…

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of…

Nicotinamide mononucleotide ameliorates the depression-like behaviors

NMN administration alleviated depression-like behavior and the liver weight to body weight ratio in a mouse model of CORT-induced depression. Transcriptome and metabolome analyses revealed that in depressed mice, NMN…

NAD + Repletion Rescues Female Fertility during Reproductive Aging

Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality…

Experts Suggest Resveratrol May Speed Up Muscle Growth

In addition to speeding up muscle growth, it is worth mentioning that resveratrol could work wonders in warding off a range of diseases and disorders. (Newswire.net — January 28, 2020)…

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration…

NICOTINAMIDE-RIBOSIDE-PROTECTS-AGAINST-LIVER-FIBROSIS-INDUCED-BY-CCL4-VIA-REGULATING-THE-ACETYLATION-OF-SMADS-SIGNALING-PATHWAY

KEY FINDINGS: We found NR could prevent liver fibrosis and reverse the existing liver fibrosis. NR inhibited the activation of LX-2 cells induced by TGF-β, activated Sirt1 and deacetylated Smad2/3. Sirt1…

Breakdowns in mitochondrial housekeeping provide another clue to Alzheimer’s culprit

Researchers have zeroed in on the role of defects in mitophagy—a process in which cells clean out damaged or defective mitochondria—as a potential new treatment target for Alzheimer’s disease in…

David Sinclair – The Future of Humanity | Xapiens Symposium

Discussion of the future of humanity . The future of our species will be majorly influenced by the technical advancements and ethical paradigm shifts over the next several decades. Artificial…

Longevity and anti-aging research: ‘Prime time for an impact on the globe’

Research into longevity and healthy aging has progressed rapidly in recent years, but intense interest from the public, corporations, and the media has created an environment in which unfounded claims…

DAVID SINCLAIR ON THE JOE ROGAN EXPERIENCE PODCAST

Check out this fascinating discussion with David Sinclair on the Joe Rogan Experience Podcast. The discussion ranges from the effects of NMN and Resveratrol to David Sinclair’s daily routines and…

Scientists identify new fuel-delivery route for cells

Scientists at Washington University School of Medicine in St. Louis have identified a previously unknown route for cellular fuel delivery, a finding that could shed light on the process of…

Slc12a8 is a nicotinamide mononucleotide transporter

Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of nicotinamide adenine dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels. How NMN…

Stunning anti-ageing breakthrough could see humans live to 150

An extraordinary new anti-ageing technique could see humans live to 150 years old and allow them to regrow their organs by 2020. Harvard Professor David Sinclair and researchers from the…

Why Jeff Bezos is backing this Silicon Valley scientist who is working on a cure for aging

According to Dr. Sinclair, “Senolytics delete zombie cells in the body which could treat age-related diseases and slow aging, the most common disease. Imagine taking a medicine every 10 years…

Longevity In A Bottle

‘Tick, tock,’ goes the clock, and with each passing second, vitality silently slips away. The slow trace of wrinkles over smooth and supple skin, the nefarious creep of aches and…

High protein intake is associated with low plasma NAD+ levels in a healthy human cohort

High protein intake and reduced levels of the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+) have both been independently associated with promotion of the ageing phenotype. However, it has not…

David Sinclair at TEDMED Discussing Resveratrol, Longevity, Endurance, and Sirtuins

Dr David Sinclair talks about longevity, Sirtuins and aging at TEDMED. Watch the Video

Scientists Can Reverse DNA Aging in Mice

Researchers have found a way to protect a mouse’s DNA from the damage that comes with aging, and they’re ready to test it in people. Dr. David Sinclair, from Harvard…

Rewinding the Clock

There are currently several human clinical trials underway that are going to help answer this very question. Dr. Sinclair has been leading the charge in this field for years. Recent…

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies…

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